Senescence as a Central Node in Alzheimer's Disease: Molecular Triggers, Cellular Effectors, and RNA-Based Interventions - PubMed
5 hours ago
- #Alzheimer's disease
- #RNA-based therapy
- #Cellular senescence
- Alzheimer's disease (AD) is characterized by amyloid-β plaques and tau tangles damaging neurons.
- Cellular senescence, triggered by stress factors like Aβ toxicity and oxidative stress, plays a role in AD pathogenesis.
- Senescent cells release proinflammatory factors (SASP), accelerating disease progression by promoting inflammation and damaging mitochondria and synapses.
- Potential treatments include targeting senescent cells via VEGFR-1, SIRT5, senolytics, senomorphs, NLRP3 antagonists, PAI-1 inhibitors, and small vessel inhibitors.
- RNA-based therapies (miRNAs and lncRNAs) and exosomal biomarkers are promising approaches for AD treatment.
- Understanding senescence in AD could lead to novel treatments to delay onset, slow progression, or preserve brain function.