Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress - PubMed
4 hours ago
- #ubiquitin-proteasome system
- #medulloblastoma
- #cell cycle
- AMBRA1 regulates degradation of p27Kip1 and p21Waf1/Cip1 via the CRL4DDB1 complex.
- Loss of AMBRA1 stabilizes p21Waf1/Cip1, causing replication stress by impairing FEN1 binding to PCNA.
- Low AMBRA1 in Sonic Hedgehog medulloblastomas correlates with high p21 levels and worse prognosis.