Herpesvirus-encoded lncRNA targets host splicing by interacting with splicing factors - PubMed
5 hours ago
- #lncRNA
- #Splicing
- #Herpesvirus
- KSHV encodes the lncRNA ALT, which is antisense to the latency region and upregulated during lytic replication.
- ALT directly interacts with 54 proteins, including 48 human splicing factors, as shown by RAP-MS.
- ALT co-localizes with splicing factors in ribonucleoprotein complexes and affects host gene splicing.
- Perturbation of ALT expression partially reverses lytic-induced host splicing changes.
- Knockdown of ALT inhibits viral reactivation and virion production, showing its role in viral replication.