NKX6.1 mRNA copy number is an actionable biomarker associated with islet function and clinical outcomes after islet transplantation - PubMed
5 hours ago
- #islet transplantation
- #biomarker
- #type 1 diabetes
- NKX6.1 mRNA copy number is a biomarker linked to islet function and clinical outcomes post-transplantation.
- The study found a linear correlation between NKX6.1 copy number and islet graft function in mice, independent of islet mass, purity, and viability.
- Total NKX6.1 copy number was more predictive of primary graft function than islet mass alone in patients receiving multiple islet preparations.
- High total NKX6.1 copy number was independently associated with 10-year survival of islet graft success and insulin independence.
- The findings were validated in an independent cohort of patients receiving single islet transplants in other centers.
- Genetic and pharmacological manipulation of NKX6.1 expression confirmed a causal relationship with islet graft function.
- NKX6.1 mRNA expression is suggested as a predictive biomarker for islet graft potency in β cell replacement therapies.