HFpEF and MASLD: converging mechanisms and clinical implications - PubMed

6 hours ago

HFpEF and MASLD are interrelated conditions driven by obesity and metabolic syndrome.
They share systemic metabolic dysfunction, with overlapping risk factors and bidirectional liver-heart crosstalk.
Key shared mechanisms include lipotoxicity, meta-inflammation, and oxidative stress.
Liver-derived mediators like hepatokines, metabolites, and extracellular vesicles influence cardiac function.
Integrated diagnostic and therapeutic strategies are needed for better management of both conditions.
Understanding the liver-heart axis is crucial for advancing cardiometabolic disease approaches.

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