Prognostic impact of immunophenotypic classification for newly diagnosed NPM1-mutated acute myeloid leukemia - PubMed
7 days ago
- #prognosis
- #immunophenotyping
- #NPM1-mutated AML
- NPM1 mutations are common in acute myeloid leukemia (AML) and associated with specific immunophenotypic features.
- The study used multiparametric flow cytometry to classify NPM1-mutated AML into seven immunophenotypic patterns based on leukemic cell populations.
- The most common pattern (33%) involved immature and monocytic leukemic cells (Pattern 4), followed by predominant immature cells (Pattern 1, 18%) and neutrophil-committed cells (Pattern 2, 18%).
- Cases with monocytic leukemic cell predominance showed a trend toward lower relapse incidence, though not statistically significant.
- The findings provide insights into the biological and immunophenotypic characteristics of NPM1-mutated AML.