The acid-sensing ion channel 1a modulates anxiety- and depression-related behaviors via its influencing on the activity of corticotropin-releasing hormone-expressing neurons in the hypothalamic parave
6 hours ago
- #CRH neurons
- #ASIC1a
- #stress modulation
- ASIC1a is co-expressed with CRH in the hypothalamic paraventricular nucleus (PVN).
- Downregulation of ASIC1a in PVN CRH neurons decreases HPA axis activity, reducing anxiety and depression-related behaviors.
- ASIC1a activation increases intracellular Ca2+ and promotes CRH expression via Ca2+/CaMKII/c-Fos signaling pathways.
- The study suggests ASIC1a as a potential therapeutic target for stress-related diseases.