Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - PubMed
11 hours ago
- #YAP/TAZ pathway
- #vocal fold cancer
- #mechanotransduction
- Increased extracellular matrix (ECM) deposition and stiffness promote vocal fold cancer progression.
- Vocal fold cancer progression is linked to cell surface receptor heterogeneity and loss of laminin-binding integrins in cell-cell junctions.
- Mimicking physiological movement (stretching/vibrations) reduces oncogenic β-catenin and YAP nuclear levels in vocal fold cancer cells.
- ECM composition, nuclear YAP levels, and patient survival are correlated in vocal fold cancer.
- Vocal fold cancer is mechanically sensitive; restoring tumor mechanophenotype or targeting YAP/TAZ may offer therapeutic benefits.