The WNK-OXSR1 osmosensing pathway mediates intestinal regeneration via Hippo-YAP signaling - PubMed
5 hours ago
- #osmosensing pathway
- #intestinal regeneration
- #Hippo-YAP signaling
- The WNK-OXSR1 osmosensing pathway plays a key role in intestinal regeneration via Hippo-YAP signaling.
- Tissue injuries disrupt osmotic balance, and the study explores osmolarity's role in regeneration using Drosophila, mouse intestine, and IBD patient samples.
- OXSR1 phosphorylates RhoB GTPase at threonine 37 upon injury, disrupting its interaction with ARHGAP17 and increasing GTP-bound RhoB levels.
- Activated RhoB enhances F-actin polymerization and YAP activation, promoting tissue regeneration.
- Pharmacological inhibition of WNK or OXSR1 reduces the oncogenic potential of intestinal regeneration.
- The findings suggest osmolarity as a critical damage signal in regeneration and WNK-OXSR1 as a potential therapeutic target for intestinal repair.