Platelet-rich plasma-derived microRNA let-7a-5p alleviates knee osteoarthritis by regulating macrophage polarization and improving inflammatory microenvironment - PubMed
12 hours ago
- #macrophage polarization
- #knee osteoarthritis
- #inflammatory microenvironment
- Platelet-rich plasma (PRP) alleviates knee osteoarthritis (KOA) by regulating macrophage polarization.
- MicroRNA let-7a-5p, derived from PRP, plays a key role in reducing inflammation and cartilage degeneration in KOA.
- PRP and let-7a-5p inhibit M1-type macrophage polarization and promote M2-type polarization, improving the inflammatory microenvironment.
- MAPK8 was identified as a target gene of let-7a-5p, contributing to the therapeutic effects on KOA.
- The study suggests PRP and let-7a-5p as potential new therapeutic targets for KOA management.