Effect of circulating exosomal miRNA-122-3p on metabolic dysfunction-associated steatotic liver disease through impairing FGFR4 expression - PubMed
5 hours ago
- #miRNA-122-3p
- #FGFR4
- #MASLD
- Exosomal miRNA-122-3p is significantly upregulated in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
- miR-122-3p promotes lipid accumulation, oxidative stress, and suppresses AMPK signaling in liver cells by targeting FGFR4.
- Engineered exosomes overexpressing miR-122-3p replicate the effects of increased triglyceride accumulation and ROS production in hepatocytes.
- The miR-122-3p/FGFR4 axis is identified as a potential therapeutic target for MASLD.