Heterobifunctional proteomimetic polymers for targeted degradation of MYC and KRAS - PubMed
4 hours ago
- #Proteomimetic Polymers
- #Biomedical Materials
- #Targeted Protein Degradation
- Introduction of HYDRAC (HYbrid DegRAding Copolymer), a polymeric platform for targeted protein degradation (TPD).
- HYDRAC integrates target-binding peptides with peptide-based or small-molecule degrons for selective degradation of proteins like MYC and KRAS.
- HYDRACs are synthetically scalable, structurally tunable, and support multivalent payload conjugation, enabling diverse target-binding and E3-ligase recruiter incorporation.
- Demonstrated efficacy in degrading MYC and KRAS in vitro and achieving durable tumor suppression in murine models.
- Potential for pan-KRAS degradation across multiple alleles using HYDRACs with consensus RAS-binding motifs.
- Authors envision HYDRACs as a generalizable paradigm to expand the TPD toolkit.