Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study - PubMed
6 hours ago
- #metagenomics
- #liver disease
- #gut microbiome
- Study explores gut microbiome changes across liver disease stages.
- Analyzed 1168 individuals with varying liver conditions using 16S rRNA sequencing and shotgun metagenomics.
- Integrated 2376 public metagenomic datasets for broader validation.
- Found microbial diversity declines as liver disease progresses.
- Identified distinct microbial and functional signatures for each disease stage.
- Hepatitis lacks taxonomic markers but shows biosynthetic upregulation.
- Advanced stages feature markers like Ligilactobacillus and Veillonella.
- Functional profiling reveals a metabolic continuum from hepatitis to carcinoma.
- Oral-derived Veillonella spp. linked to increased mortality.
- Highlights microbiome-based markers for non-invasive diagnosis and prognosis.