ALDH1L2 induces resistance to chemotherapy in small cell lung cancer by inhibiting ferroptosis - PubMed
5 hours ago
- #Chemoresistance
- #Ferroptosis
- #ALDH1L2
- ALDH1L2 expression is linked to poor prognosis in small cell lung cancer (SCLC).
- High ALDH1L2 levels inhibit ferroptosis by reducing cellular lipid peroxidation, leading to chemoresistance.
- ALDH1L2 interacts with the TRX2-PRDX3 antioxidant network to decrease oxidized PRDX3 levels under cisplatin-induced stress.
- Thiostrepton, a PRDX3 inhibitor, shows potential in overcoming SCLC chemoresistance when combined with chemotherapy.