Integrative Transcriptomic Profiling Reveals Molecular Signatures of Disease Progression from Gastroesophageal Reflux Disease to Barrett's Esophagus: A Foundation for Single-Cell Resolution Studies -
7 hours ago
- #Transcriptomics
- #GERD
- #Barrett's Esophagus
- Study focuses on molecular transition from GERD to Barrett's Esophagus (BE), a precancerous condition.
- Utilized bulk RNA-sequencing on 40 patients (20 GERD, 20 BE) to identify transcriptomic changes.
- Found 1,247 differentially expressed genes between GERD and BE, with significant roles in extracellular matrix remodeling and immune response.
- Key pathways identified include PI3K-Akt and cell cycle regulation, indicating early signs of malignant transformation.
- Specific genes like MMP7, CDH17, and CXCL8 correlated with disease severity and treatment resistance.
- Study provides a foundation for future single-cell resolution studies to further understand disease progression.