DDX5 orchestrates RNA homeostasis to ensure oocyte developmental competence - PubMed
a day ago
- #oocyte development
- #RNA homeostasis
- #DDX5
- DDX5 is identified as a key regulator of RNA homeostasis in oocytes.
- Oocyte-specific deletion of DDX5 leads to female sterility due to defects in chromatin remodeling, meiotic arrest, increased aneuploidy, and fertilization failure.
- DDX5 maintains RNA homeostasis through three processes: promoting transcription, clearing retrotransposon RNAs, and supporting maternal mRNA storage.
- The study establishes DDX5 as a master regulator integrating transcriptional and post-transcriptional programs for oocyte competence and fertility.