Therapeutic targeting of DNA repair pathway dysregulation in aging, cancer, and neurodegeneration - PubMed
4 hours ago
- #therapeutic targeting
- #aging cancer neurodegeneration
- #DNA repair
- Genome maintenance is a key vulnerability in aging, cancer, and neurodegeneration, with therapeutic implications of DNA repair dysregulation still not fully understood.
- The review covers dysregulation in multiple DNA repair pathways (base excision, nucleotide excision, mismatch, homologous recombination, non-homologous end joining) and drivers like oxidative stress and telomere dysfunction.
- In aging and neurodegeneration, repair defects lead to senescence and inflammation; in cancer, tumor cells rewire repair for survival and resistance.
- Biomarkers for repair states and emerging therapies targeting molecules such as PARP, ATR, ATM, DNA-PK, POLQ, and cGAS-STING are summarized.
- Clinical success depends on context-specific repair states and dependencies, enabling tailored treatments to restore repair in aging/neurodegeneration or exploit repair addiction in cancer.