The role of therapeutic alliance in psilocybin treatment for treatment-resistant depression: A post hoc path analysis - PubMed
5 hours ago
- #therapeutic alliance
- #treatment-resistant depression
- #psilocybin
- Study explored therapeutic alliance in psilocybin treatment for TRD via path analysis.
- Therapeutic alliance had weak correlation with depression score changes compared to psychedelic experience measures.
- Path analysis showed no direct effect of alliance on outcomes but indirect effects via psychedelic experiences.
- Psychedelic experiences (EBI, Oceanic Boundlessness, etc.) strongly influenced clinical outcomes.
- Conclusions: Alliance facilitates psychedelic experience, which drives therapeutic efficacy, with limited direct alliance effects.