Updates in the Treatment of Pediatric Pulmonary Arterial Hypertension - PubMed
5 hours ago
- #pharmacotherapy
- #treatment guidelines
- #pediatric pulmonary hypertension
- Pediatric pulmonary arterial hypertension (PAH) is a severe disease with elevated pulmonary vascular resistance and pressure due to vascular remodeling.
- Treatment guidelines for pediatric PAH in the U.S. are based on limited trials and expert opinion, often extrapolated from adult data.
- Key treatments include endothelin receptor antagonists, phosphodiesterase-5 inhibitors, and prostacyclin-pathway agents.
- Recent advances focus on monotherapy vs. combination regimens and trials for interventional/surgical procedures.
- There is a need for updated pediatric-specific pharmacological guidelines incorporating trials and long-term safety data.