Basophils drive the resolution and promote wound healing in adult and aged mice - PubMed
5 hours ago
- #Inflammation Resolution
- #Basophils
- #Wound Healing
- Basophils accumulate in perivascular areas around mouse skin wounds for over three weeks, influencing both inflammation and resolution phases.
- Depleting basophils leads to increased inflammatory molecule secretion, pro-inflammatory leukocyte accumulation, and delayed wound healing.
- Basophil-derived IL-4 promotes epidermal differentiation towards homeostasis, enhancing healing resolution.
- Aged mice exhibit stronger basophil infiltration into wounds, which aids inflammation resolution more effectively.
- Basophils are identified as pro-resolution cells, suggesting potential new strategies to combat chronic wounds in the elderly.