Anshen Bunao Syrup alleviates depression on CUMS rats by reducing neuroinflammation: Integral insights from transcriptomics, microbiomics, and metabolomics - PubMed
8 hours ago
- #gut-brain axis
- #neuroinflammation
- #depression treatment
- Anshen Bunao Syrup (ABS) alleviates depression in CUMS rats by reducing neuroinflammation.
- ABS improved depressive behaviors and increased dopamine and serotonin levels in the brain.
- It mitigated hippocampal damage, reduced microglial activation, and lowered oxidative stress.
- ABS modulated gut microbiota, enhanced gut function, and suppressed HPA axis hyperactivity.
- Metabolomics showed ABS corrected metabolic disturbances and reduced inflammation.
- Transcriptomics identified regulation of the Npas4-BDNF-PI3K/AKT pathway, confirmed by Western Blot.
- The study provides multi-omics insights into ABS's antidepressant mechanisms via the gut-brain axis.