Spatial heterogeneity of MDSCs mediated by ANXA1-FPRs signaling drives immune suppression in OSCC progression - PubMed
5 hours ago
- #OSCC
- #MDSCs
- #Immunotherapy
- Limited efficacy of immunotherapy in OSCC due to immunosuppressive tumor microenvironment.
- Spatial transcriptomics reveals CD8+ T cells are localized but suppressed in late-stage OSCC.
- MDSCs transition from tumor core infiltration in early-stage to marginal localization with CD8+ T cells in advanced OSCC.
- ANXA1-FPR2 signaling mediates tumor-MDSCs communication, sustaining MDSCs recruitment and immune suppression.
- Disrupting ANXA1-FPR2 with an antagonist enhances immune checkpoint blockade therapy efficacy in OSCC mouse models.
- Findings highlight MDSCs spatial dynamics as key modulators of immune suppression and therapeutic resistance.