Immunometabolic Reprogramming in Experimental Sepsis: A Driver of Multiple Organ Dysfunction Syndrome - PubMed
2 days ago
- #immunometabolism
- #organ dysfunction
- #sepsis
- Sepsis is a life-threatening syndrome caused by infection-induced systemic inflammation and immune dysregulation, often leading to multiple organ dysfunction syndrome (MODS).
- Immunometabolic reprogramming is a critical mechanism in sepsis progression, involving metabolic alterations in immune cells and organs.
- Key metabolic features include enhanced glycolysis, impaired mitochondrial function, and disturbed lipid metabolism, linked to organ damage.
- These metabolic changes affect immune responses, cell fate decisions, inter-organ crosstalk, and MODS development.
- The review highlights temporal progression of pathological changes in animal models and organ-specific metabolic dysfunctions.
- Dynamic immunometabolic regulation, tissue-specific responses, and inter-organ interactions are crucial for sepsis treatment.
- Multi-omics technologies, reliable biomarkers, and personalized therapeutic strategies are needed for clinical translation.