Recent Advances in Nanoscale Sprayable Hydrogels for Cancer Management: Nanoparticle-Loaded Formulations for Therapy and Prevention - PubMed
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- #drug-delivery
- #cancer-therapy
- #nanotechnology
- Sprayable hydrogels are emerging as nanoscale, localized drug delivery systems in oncology.
- Recent advances integrate nanotechnology into sprayable hydrogels to enhance therapeutic efficacy.
- Preclinical models show 70-95% reductions in residual tumor burden and 2-5-fold increases in intratumoral drug retention.
- These hydrogels can eliminate residual tumor cells, activate antitumor immunity, and prevent recurrence.
- Therapeutic modalities include controlled release of chemotherapeutics, immune checkpoint inhibitors, and metabolic regulators.
- Over 80% suppression of local recurrence at surgical margins has been reported.
- Applications include peritoneal carcinomatosis, superficial skin tumors, and premalignant mucosal lesions.
- Hydrogels are made from nanostructured materials like thermosensitive polymers and self-gelling powders.
- Challenges include sterilization constraints, device-material compatibility, and regulatory hurdles.