Association of Autoimmune Diseases With Pancreatic Cancer: A Nationwide Follow-Up Study From Sweden - PubMed
4 days ago
- #autoimmune diseases
- #epidemiology
- #pancreatic cancer
- The study investigates the association between autoimmune diseases (ADs) and pancreatic cancer (PC) using nationwide data from Sweden.
- A cohort of 16.4 million people was analyzed, identifying 1.1 million AD cases and 3,257 PC cases (5.42% of all cancers in the cohort).
- Standardized incidence ratios (SIRs) for PC were 1.24 (men) and 1.19 (women); 12 ADs showed a positive correlation with PC incidence.
- Standardized mortality ratios (SMRs) for PC were 1.28 (men) and 1.22 (women); 15 ADs were linked to higher PC mortality.
- Short-term follow-up (<1 year) showed a PC risk of 3.88 in AD patients, decreasing to 1.12 over 10 years.
- New associations were found between PC and ADs like discoid lupus erythematosus, lupoid hepatitis, giant-cell arteritis, and rheumatic fever.
- The study supports the hypothesis that ADs may contribute to the development of PC.