HDAC7 is a key factor for the germinal center reaction and its underexpression is associated with DLBCL prognosis - PubMed
5 hours ago
- #Germinal Center
- #DLBCL
- #HDAC7
- HDAC7 is essential for the formation of germinal centers (GC).
- HDAC7 deficiency leads to aberrant GCB cells, reduced class switch recombination (CSR), and impaired plasma cell (PC) formation.
- Low HDAC7 expression in diffuse large B cell lymphoma (DLBCL) is linked to poor patient prognosis.
- HDAC7 expression in DLBCL cell lines reduces proliferation and tumorigenicity in vivo.
- The study highlights HDAC7's role in GC establishment and its potential deregulation in DLBCL.