Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers - PubMed

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The study compared PET and plasma-based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease.
Longitudinal data from ADNI and Penn ADRC were used, including amyloid PET, tau-PET, and plasma p-tau217.
The sampled-iterative Local approximation (SILA) method was employed to generate biomarker trajectory models.
Plasma and PET models showed similar results for amyloid and tau onset, with stronger agreement for tau onset.
Accuracy of estimated onset was high within modality but slightly less accurate when comparing across modalities.
Earlier tau onset was associated with younger amyloid onset, female sex, and ≥1 ApoE ε4 allele.
Earlier dementia onset after tau was linked to later tau onset for both plasma and PET models.
Male sex was associated with a shorter tau to dementia gap in plasma models.
Plasma biomarker modeling provides comparable information to PET, especially for tau onset age.
Plasma biomarkers can serve as a widely accessible tool for assessing biological disease severity.

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