Gas-sensing neurons prime mitochondrial fitness to offset metabolic stress - PubMed
4 hours ago
- #mitochondrial stress
- #gas-sensing neurons
- #metabolic adaptation
- The mitochondrial unfolded protein response (UPRmt) helps cells alleviate proteotoxicity caused by metabolic stress.
- Caenorhabditis elegans receptor guanylyl cyclase GCY-9 regulates neuropeptide signaling from CO2-sensing neurons to manage a noncanonical mitochondrial stress response in the intestine.
- This noncell autonomous stress response leads to atypical mitochondrial chaperone transcription, stress resistance, and increased mitochondrial membrane potential and respiration.
- Starvation reduces GCY-9 expression, triggering a cytoprotective program to mitigate metabolic and proteotoxic risks.
- Environmental sensing by peripheral neurons can preemptively boost systemic mitochondrial function during metabolic uncertainty.