Binge drinking, metabolic dysfunction, and the spectrum of steatotic liver disease in the USA: a cross-sectional and longitudinal analysis - PubMed
5 hours ago
- #steatotic liver disease
- #public health interventions
- #alcohol underreporting
- The study adjusted for underreported alcohol intake to reclassify steatotic liver disease, revealing higher burdens of MetALD and ALD than previously recognized.
- From 1988-90 to 2021-23, prevalence increased significantly for MASLD (12.69% to 28.16%), MetALD (1.62% to 4.10%), and ALD (2.28% to 4.59%), with alcohol underreporting substantially affecting ALD and MetALD estimates.
- Premature mortality rates were highest for ALD (14.91 per 1000 person-years), followed by MetALD (8.74) and MASLD (7.86), compared to abstainers without liver disease (4.76).
- Type 2 diabetes was the strongest metabolic predictor of premature mortality in MASLD, while binge drinking was the dominant driver in MetALD and ALD, with synergistic risks when combined with diabetes or hypertension.
- Findings highlight the need for systematic alcohol screening, especially for binge drinking, and comprehensive assessment of cardiometabolic risk factors in public health and clinical interventions.