Chikungunya virus persists in joint-associated macrophages and promotes chronic disease in mice - PubMed
5 hours ago
- #Macrophage Persistence
- #Chikungunya Virus
- #Chronic Arthritis
- Chikungunya virus (CHIKV) persists in joint-associated macrophages, contributing to chronic musculoskeletal disease in mice.
- Inflammatory macrophages in joint tissues harbor CHIKV RNA, indicating ongoing viral replication during chronic infection.
- CD4+ T cells expressing Ifng accumulate in joints, and their depletion reduces MHC class II expression on macrophages, implicating them in inflammation.
- Treatment with an inhibitor of CHIKV replication during chronic disease reduces viral RNA and joint inflammation.