Metronidazole and ether derivatives target Helicobacter pylori via simultaneous stress induction and inhibition - PubMed
7 hours ago
- #Metronidazole
- #Helicobacter pylori
- #Antibacterial
- Metronidazole is a front-line drug for treating Helicobacter pylori infections.
- The study identified chaperonin HpGroEL and thiol peroxidase HpTpx as key targets of metronidazole.
- Alkynylated ether probes showed enhanced antibacterial potency, including against resistant strains.
- Ether derivatives exhibited favorable pharmacological profiles without cytotoxicity.
- In vivo studies demonstrated full bacterial eradication at low dosing (0.3 mg kg-1 day-1).
- The mechanism involves stress induction and simultaneous inhibition of the stress response.