Exploring the metabolic mysteries: Mechanistic insights into lactylation-mediated regulation of autoimmune diseases - PubMed
14 hours ago
- #Metabolic reprogramming
- #Autoimmune diseases
- #Lactylation
- Autoimmune diseases result from the immune system mistakenly attacking self-tissues.
- Lactylation, a post-translational modification driven by lactate, connects metabolism to immune regulation.
- Lactate influences immune responses in both innate and adaptive immunity through lactylation.
- Lactylation plays a role in diseases like rheumatoid arthritis, lupus, inflammatory bowel disease, and Sjögren's syndrome.
- Lactylation affects disease progression by modulating inflammation, immune cell infiltration, and tissue damage.
- Lactylation-associated genes and modification levels may serve as biomarkers for autoimmune diseases.
- Targeting lactate metabolic pathways or enzymes offers potential therapeutic strategies for autoimmune diseases.