An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia - PubMed
4 days ago
- #ENIGMA
- #white matter
- #schizophrenia
- Study examines the relationship between white matter microstructure and symptom severity in schizophrenia.
- Positive symptom severity is associated with temporal lobe and global fractional anisotropy (FA).
- Negative symptom severity initially showed no significant association with frontal lobe or global FA.
- Heterogeneity across sites for negative symptoms was partly explained by duration of illness.
- Post-hoc analysis revealed a significant association between negative symptoms and global/frontal FA after removing an outlier site.
- Findings support schizophrenia as a disorder of brain connectivity linked to symptom severity.