Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging - PubMed
4 hours ago
- #osteoporosis
- #miR-125a-5p
- #extracellular vesicles
- Atrophic skeletal muscle-derived extracellular vesicles (Aged-SKM-EVs) inhibit bone formation during aging.
- Aged-SKM-EVs are taken up by osteoblasts and suppress osteogenic differentiation.
- Blocking muscle EV generation with GW4869 restores osteoblast activity and reduces bone loss in aged mice.
- miR-125a-5p is a key cargo in EVs from sarcopenic patients and aged mice, inhibiting osteogenesis.
- Overexpression of miR-125a-5p worsens muscle atrophy and bone loss, while silencing it reverses these effects.
- miR-125a-5p targets Sirt7 in preosteoblasts, disrupting SIRT7-mediated histone deacetylation and Sp7 transcription.