EARLY INTERVENTION PREVENTS DISEASE PROGRESSION IN ULCERATIVE COLITIS - A MULTICENTER RETROSPECTIVE STUDY - PubMed
5 hours ago
- #Biologic Therapy
- #Ulcerative Colitis
- #Early Intervention
- Early biologic therapy (BT) within 12 months of diagnosis may prevent disease progression in ulcerative colitis (UC).
- A multicenter retrospective study involving 236 UC patients with at least 5 years of follow-up was conducted.
- Late BT initiation was associated with a higher risk of disease progression, including proximal extension and colonic structural damage.
- Early BT reduced the risk of proximal disease extension (28.6% vs. 0.0%).
- No significant differences were observed in clinical outcomes like hospitalizations, surgery, or corticosteroid use.
- The study suggests an early 'window of opportunity' in UC to mitigate long-term disease progression.