Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism - PubMed
7 days ago
- #biomarkers
- #proteomics
- #venous thromboembolism
- Study identifies novel plasma protein biomarkers for venous thromboembolism (VTE) using large-scale proteomics.
- Included 4 longitudinal cohorts (ARIC, CHS, MESA, HUNT) with 20,737 participants and 1,371 incident noncancer VTEs.
- Used SomaScan to measure 5,000-7,000 plasma proteins, examining prospective relationships with VTE risk.
- 23 proteins significantly associated with VTE, 15 of which are newly identified.
- Three new proteins (TAGLN, SVEP1, TIMP4) showed strong significance in replication cohort (HUNT).
- 11 out of 16 top proteins replicated in UK Biobank (UKB) study using Olink proteomics.
- Mendelian randomization (MR) suggested possible causal roles for TIMD4, TIMP4, and CST3 in VTE risk.
- Findings highlight new biological pathways (extracellular matrix regulation, immunity, vascular senescence) for VTE.
- Results may improve VTE risk stratification, prevention, and treatment strategies.