Within-Person Seasonal Variability of Aminotransferases and Long-Term Glycemic Control in Adults With Type 2 Diabetes (JDDM 85) - PubMed
5 hours ago
- #Liver Enzymes
- #Type 2 Diabetes
- #Seasonal Variation
- AST and ALT levels in adults with type 2 diabetes show significant seasonal variation, peaking in late autumn/early winter and reaching their lowest in summer.
- Approximately one in nine patients near the common ALT threshold (30 IU/L) for MASLD screening would be reclassified as normal or abnormal based on season (winter vs. summer).
- Greater seasonal amplitude in AST was independently associated with higher final HbA1c levels and increased odds of not achieving HbA1c < 7%, indicating worse long-term glycemic control.
- Seasonal amplitude in ALT showed a similar but weaker and less consistent association with glycemic outcomes compared to AST.
- The findings suggest that season-aware interpretation of aminotransferase levels is important in clinical practice for patients with type 2 diabetes.