Molecularly Engineered Phenoxazinone-Skeleton Cascade-Activated NIR Probes for Monitoring Fe2+/Viscosity in Ferroptosis-Mediated Parkinson's Disease - PubMed
6 hours ago
- #near-infrared probes
- #Parkinson's disease
- #ferroptosis
- Parkinson's disease (PD) is the second most common neurodegenerative disease, with ferroptosis potentially leading to dopaminergic neuron death.
- Accumulated ferrous ions (Fe2+) and increased intracellular viscosity promote ferroptosis, making monitoring Fe2+/viscosity crucial for PD theranostics.
- A series of Fe2+/viscosity cascade-activated near-infrared fluorescence probes (NP1-5) were synthesized, with NP3 identified as the optimal probe.
- NP3 monitors Fe2+/viscosity via redox reactions and twisted intramolecular charge transfer processes.
- An innovative nanoplatform (PQR NPs) was constructed using NP3 and quercetin, modified with rabies virus glycoprotein-29.
- PQR NPs alleviate ferroptosis-induced neuron loss by reducing oxidative stress, neuroinflammation, mitigating α-synuclein aggregation, and restoring mitochondrial function.
- PQR NPs also monitor elevated Fe2+/viscosity in PD models, offering potential for PD and other ferroptosis-related diseases.