Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice - PubMed
4 hours ago
- #Glioblastoma
- #Cancer therapy
- #Akt-Wnt signaling
- Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice.
- Glioblastoma (GBM) is an aggressive brain tumor with poor survival rates and limited treatment options.
- The PI3K/Akt and Wnt/β-catenin pathways promote GBM cell growth, survival, invasiveness, and therapeutic resistance.
- MK-2206 (pan-Akt inhibitor) and iCRT3 (β-catenin inhibitor) were tested in vitro on mouse and human glioma cells.
- MK-2206 reduced cell viability, induced apoptosis, and inhibited β-catenin activity more effectively than iCRT3.
- In vivo studies showed MK-2206 suppressed tumor growth and reduced phosphorylated Akt and GSK-3β expression.
- Akt inhibition via MK-2206 may be a promising therapeutic strategy for GBM with dysregulated PI3K/Akt or Wnt/β-catenin pathways.