HIV-1-encoded circular RNA enhances viral transcription through Tat binding - PubMed
5 hours ago
- #circRNA
- #HIV-1
- #viral transcription
- HIV-1 encodes a circular RNA (circHIV) detected in plasma from people living with HIV and infected cells.
- circHIV is packaged within HIV-1 virions and binds to the HIV-1 Tat protein.
- Binding of circHIV to Tat enhances transcription from the viral promoter.
- The study reveals circRNAs as transcriptional regulators in viral pathogenesis.