Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors - PubMed
5 hours ago
- #gene therapy
- #gut microbiota
- #serotonin signaling
- Gut microbiota significantly influence the efficacy of in vivo delivery systems (IDSs) for therapeutics.
- Disrupting commensal-host interactions enhances drug and gene delivery efficiency.
- Intestinal epithelial cells activate Kupffer cells via serotonin production, leading to hepatic IDS clearance.
- Suppressing serotonin signaling improves delivery efficiency, with notable therapeutic enhancements in various therapies.
- The gut-liver immune axis can be exploited to enhance IDS-based cancer and gene therapies.