Prognosis in Parkinson's Disease: An Individual Patient Data Meta-Analysis of Six European Incidence Cohorts - PubMed
5 hours ago
- #Parkinson's disease
- #prognosis
- #meta-analysis
- The study is an individual patient data meta-analysis of six European incidence cohorts for Parkinson's disease (PD).
- It aimed to provide robust prognosis data with less selection bias, using population-representative cohorts from Norway, Sweden, and UK.
- Key outcomes included postural instability (median onset 7.4 years), functional dependency, dementia (affecting 49.6% by 10 years), and death (median survival 9.4 years).
- Predictors for worse outcomes included older age, higher MDS-UPDRS-III score, lower MMSE score, cognitive symptoms, and specific genetic factors (GBA polymorphisms and APOE ε4).
- The study concluded that PD prognosis is worse than previously thought, with key outcomes often occurring early, highlighting the need for validated prognostic models.