Cell stress and death liberate the autophagy-inhibitory tissue stress hormone DBI/ACBP into the circulation - PubMed
3 hours ago
- #Autophagy
- #Cell Death
- #Stress Response
- Cell stress and death release DBI/ACBP, an autophagy-inhibitory hormone, into circulation.
- DBI/ACBP acts as a feedback inhibitor of autophagy, promoting metabolic and inflammatory changes.
- Regulated cell death (apoptosis, ferroptosis, necroptosis) causes DBI/ACBP release via plasma membrane permeabilization.
- Elevated plasma DBI/ACBP is linked to aging, inflammation, organ dysfunction, and increased morbidity in humans.