Single-Cell Transcriptomics Reveals Biomarkers for NK Cell Dysfunction in Endometriosis-Associated Immune Dysregulation - PubMed
5 hours ago
- #biomarkers
- #endometriosis
- #NK cell dysfunction
- Single-cell RNA sequencing (scRNA-seq) was used to study immune dysregulation in endometriosis (EM), focusing on natural killer (NK) cell dysfunction.
- The study identified three key genes (GNLY, PRF1, ENTPD1) as potential biomarkers for NK cell dysfunction in EM.
- GNLY and PRF1 were predominantly expressed in NK and CD8+ T cells, correlating with activation signatures.
- ENTPD1, highly expressed in endometrial stromal cells, enhanced cell migration and invasiveness, possibly via adenosine signaling-mediated NK-cell modulation.
- The three-gene model showed good diagnostic potential in training and validation cohorts (AUCs 0.84, 0.67, and 0.77).
- Candidate therapeutic agents targeting the ENTPD1 pathway include resveratrol, ibuprofen, and danazol.
- The findings suggest ENTPD1 has dual roles in immunomodulation and stromal cell migration, contributing to EM lesion formation.