Neuroprotective effect of astrocytic dopamine Drd2 receptor on mitochondrial complex I in a mouse model of Parkinson's disease through β-arrestin2-NDUFA10 regulation - PubMed
4 hours ago
- #Parkinson's disease
- #astrocytic D2 receptor
- #mitochondrial complex I
- The study reveals the neuroprotective role of astrocytic dopamine D2 (Drd2) receptors in Parkinson's disease (PD) by improving mitochondrial function in a mouse model.
- Deletion of astrocytic Drd2 receptors worsens mitochondrial dysfunction, as shown by transcriptome sequencing and metabolomics.
- Mechanistically, Drd2 activation recruits β-arrestin2 to regulate mitochondrial complex I activity by interacting with subunits NDUFA4 and NDUFA10.
- Knockdown of NDUFA10 in astrocytes abolishes the neuroprotective effects of Drd2 activation, highlighting its critical role.
- The findings provide a new framework for developing combination therapies targeting mitochondrial dysfunction and dopamine receptor dysregulation in PD.