Drug-Induced Osteoporosis - PubMed
8 days ago
- #drug-induced
- #osteoporosis
- #bone-health
- Drug-induced osteoporosis is a form of secondary osteoporosis caused by medications, leading to bone loss and increased fracture risk.
- Medications can directly affect osteoblasts and osteoclasts, impairing bone remodeling, or indirectly impact bone health through calcium/vitamin D metabolism or hypogonadism.
- Common drug classes linked to osteoporosis include glucocorticoids, aromatase inhibitors, androgen-deprivation therapy, proton pump inhibitors, and antidepressants.
- Bone health should be monitored in patients on long-term bone-damaging medications, including lab tests, fracture risk assessment (e.g., FRAX®), and bone density measurements.
- Ensuring adequate calcium and vitamin D intake and initiating guideline-based osteoporosis therapy when necessary is recommended.