Herpes Simplex Virus Type 1 Infects Schwann Cells via Exosomal CD81, Exploits the MVB-Exosomal Pathway, and Induces Demyelination - PubMed
4 hours ago
- #Schwann cells
- #HSV1
- #demyelination
- HSV1 productively infects Schwann cells, but infection efficiency depends on the viral strain.
- HSV1 hijacks the MVB-exosomal pathway in Schwann cells for efficient infection and spread, with TEM showing MVBs containing virions.
- HSV1 uses tetraspanin CD81 as the main entry receptor into Schwann cells, demonstrated via function-blocking antibody and siRNA treatments.
- HSV1 downregulates expression of the myelin-related PMP22 gene at late infection stages.
- In vivo studies confirm HSV1 infection induces PNS demyelination, with loss of MBP expression and demyelinating lesions observed in infected tissues.
- This study provides new insights into Schwann cells' role in herpesvirus pathogenesis and viral-induced demyelination.