Revealing Biological Mechanisms of Skin Pigment Recovery during Treatment in Vitiligo Patients; A Proteomic Analysis - PubMed
4 hours ago
- #proteomics
- #skin-repigmentation
- #vitiligo
- Vitiligo is an autoimmune disease causing skin depigmentation due to autoreactive CD8 T-cells.
- Proteomic analysis of 30 vitiligo patients identified 5 proteins linked to skin repigmentation during treatment.
- Higher baseline levels of TIM-1, TFF3, and NLRP1 in blister-fluid, and increased KRT5 in plasma, were associated with repigmentation.
- TIM-1 and TFF3 have immunosuppressive effects, while NLRP1 and KRT5 stimulate melanogenesis.
- The NLRP1-inflammasome pathway was enriched, suggesting treatment involves processes beyond reversing lesional to non-lesional skin.
- Findings enhance understanding of repigmentation and may guide future vitiligo therapies.