Real-World Effectiveness of Tirzepatide in Japanese Patients with Type 2 Diabetes: A Multicenter Retrospective Observational Study - PubMed
4 hours ago
- #Type 2 Diabetes
- #Tirzepatide
- #Real-World Evidence
- Tirzepatide demonstrated real-world effectiveness in improving glycemic control and reducing body weight in Japanese patients with type 2 diabetes over 24 weeks.
- Significant reductions in HbA1c (median decrease -0.9%) and body weight (median decrease -2.0 kg) were observed, with benefits varying by patient characteristics.
- Greater HbA1c reduction was seen in GLP-1 receptor agonist-naïve patients and correlated with higher baseline HbA1c levels, but not with BMI.
- The study was a multicenter retrospective observational analysis involving 324 patients, with diverse tirzepatide dosing (5 mg being most common at 65.1%).
- Results suggest tirzepatide is a viable treatment option across diverse treatment backgrounds in real-world clinical practice in Japan.