Effectiveness and Safety of Antidiabetic Medications in Hidradenitis Suppurativa: A Systematic Review - PubMed
6 hours ago
- #Metformin
- #Antidiabetic medications
- #Hidradenitis suppurativa
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition associated with metabolic dysfunction and insulin resistance.
- Antidiabetic medications, including metformin, GLP-1 receptor agonists, and SGLT2 inhibitors, were evaluated for their effectiveness and safety in HS management.
- Metformin was the most studied drug, showing reductions in HS lesion counts, flare frequency, and disease severity scores.
- Quality of life improvements were observed with metformin, liraglutide, and tirzepatide, as measured by the Dermatology Life Quality Index (DLQI).
- Gastrointestinal side effects were common with metformin, but no severe adverse events were reported for GLP-1 receptor agonists or SGLT2 inhibitors.
- The study concludes that antidiabetic medications, particularly metformin and GLP-1 receptor agonists, are beneficial for HS with a favorable safety profile.
- Further high-quality randomized controlled trials are needed to confirm these findings.